Efficacy of Cardioprotective Effects in Ethanolic Extract of Sida Rhombifolia Linn. On Isoproterenol-Induced Myocardial Infarction in Albino Rats

The present study was designed to investigate whether Sida rhombifolia Linn (Malvaceae), a natural herb, would attenuate the acute myocardial infarction in isoproterenol (ISP)-treated rat model via maintaining cardiac function and activities of endogenous antioxidant enzymes. Heart tissue enzyme analysis in albino (Wistar) male rats, such as LPO, GSH, GPX, GST, SOD, CAT, CK-MB, MDA and biochemical analysis in serum plasma viz., ALT, AST, LDH, CPK were performed. Ethanolic extract of Sida rhombifolia (SRE) at the dose of (100& 200 mg/kg/p.o) produced significant salvages the heart from isoproterenol induced myocardial ischemic injury. The results indicate that SRE administration causes myocardial adaptation by augmenting endogenous antioxidants and protects rat hearts from decline in cardiac function and oxidative stress associated with ISP induced myocardial injury, and justify its potential therapeutic value in the treatment of ischemic heart diseases in albino rats.